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Technical Data Sheet
Eastman™ C-A-P Cellulose Ester NF (Pellets)


Applications
  • Pharmaceutical excipients

Product Description
Eastman™ C-A-P (Cellulose Acetate Phthalate, NF) enteric coating material is a pH-sensitive cellulose derivative designed for coating pharmaceutical tablets, capsules or granules. It may also be used as a matrix material in solid dose forms. C-A-P enteric coating material withstands prolonged contact with acidic gastric fluids, but it dissolves readily in the mildly acidic to neutral environment of the small intestine. It can be applied to tablets, capsules or granules from solutions of organic solvents. C-A-P meets USP and NF specifications and is available in powder and pellet form.

Typical Properties

PropertyTypical Value, Units
General
FormaWhite pellets
Composition 
     Acetyl21.5-26 %
     Free Acid as Phthalic Acid3.0 wt % max.
     Moisture5.0 wt % max.
     Phthalyl30-36 %
Viscosityb 
     @ 25°C45-90 cP

aPelleted C-A-P exhibits slower dissolution time in poor solvents such as ethyl acetate/isopropanol blends. Acetone or acetone blends are the preferred solvents for C-A-P pellets.
bCentipoise, 15% C-A-P in an acetone solution (68 cP = 80.5 centistokes)



Comments
Properties reported here are typical of average lots. Eastman makes no representation that the material in any particular shipment will conform exactly to the values given.


Eastman and its marketing affiliates shall not be responsible for the use of this information, or of any product, method, or apparatus mentioned, and you must make your own determination of its suitability and completeness for your own use, for the protection of the environment, and for the health and safety of your employees and purchasers of your products. No warranty is made of the merchantability of fitness of any product, and nothing herein waives any of the Seller's conditions of sale.